ΒΆ Molecular Evolution, Protein Engineering and Production Facility (MEPEP) |
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| Hall for Discovery and Learning Research 207 S. Martin Jischke Dr., West Lafayette, IN 47907 https://www.purdue.edu/discoverypark/pi4d/facilities/mepep/index.php Contact: Raluca Ostafe, PhD; rostafe@purdue.edu |
Education and Research | |
| Role(s) | The Molecular Evolution, Protein Engineering, and Production (MEPEP) Facility, part of the Purdue Institute of Inflammation, Immunology and Infectious Disease (PI4D), is a discovery resource facility designed to serve the research community at Purdue University and their partner institutions and organizations |
| Mission | MEPEP is focused on bringing multiple research areas together and filling the gaps that exist in individual research groups by providing know how and top of the line infrastructure/equipment to address recombinant protein expression, purification, optimization, and characterization |
| History | MEPEP was founded in 2019 |
| Org | MEPEP has a staff of three people. Additional people are hired based on project needs. Leadership: Raluca Ostafe, PhD, Director |
| Board | MEPEP is not a board run institution |
| Finance | MEPEP is supported by research projects from Purdue University and its partner institutions as well as by research contracts from industry partners |
| Data Source | N/A |
| Data Access | N/A |
| Tech Capabilities | MEPEP focuses on recombinant protein production using E. coli, Bacillus, yeast and mammalian cell lines; protein purification; protein optimization by directed evolution and protein engineering including the development of ultra-high-throughput screening system based on FACS and microfluidic devices; protein characterizations related to kinetics or protein-protein interactions (SPR) |
| Projects | MEPEP is involved in multiple projects in collaboration with industrial and non-profit partners covering a multitude of topics from antibody discovery & production, vaccine development, new diagnostics and novel antimicrobial compound discovery |
| Future Focus | Increase the number of collaborations and developed standardized methodologies that can help bring products closer to the market |
| Talent Development | MEPEP has multiple interns, undergrad and graduate students working in the labs every year |
| Data Sharing Agreements | Data sharing agreements are project specific |
| Program/Publications | Annual Reports, Newsletters |