¶ Purdue Institute for Integrative Neuroscience (PIIN) |
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| 207 S. Martin Jischke Drive, West Lafayette, IN 47907 https://www.purdue.edu/dp/neuroscience Contact: neuro@purdue.edu Twitter: @PurdueLifeSci |
Education, Research, and Training |
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| Role(s) | • Located in Discovery Park at Purdue University, the Purdue Institute for Integrative Neuroscience (PIIN) fosters interdisciplinary partnerships among life scientists and engineers, as well as basic scientists and clinicians. • The Institute aims to achieve national and international impact by unraveling the mysteries of normal brain function and elucidating molecular underpinnings of neurologic disease. |
| Mission | The mission of the Purdue Institute for Integrative Neuroscience is to bring together experts in science and engineering to unravel the mysteries of the healthy brain, as well as alleviate suffering associated with trauma, disease, or disorders of the nervous system, through biomedical discoveries and creative technologies. |
| History | 2016 – Established as one of the institutes in Purdue’s Pillars of Excellence in Life Sciences initiative. |
| Org | Members of PIIN - Faculty and staff - >140 across 6 colleges and 25 departments Leadership Team: • Jean-Christophe (Chris) Rochet – John and Donna Krenicki Director (jrochet@purdue.edu) • Edward Bartlett (ebartle@purdue.edu) • Michael Heinz (mheinz@purdue.edu) • Sebastien Helie (shelie@purdue.edu) • Peristera (Perry) Paschou (ppaschou@purdue.edu) • Riyi Shi (riyi@purdue.edu) |
| Board | The Liaison Committee provides guidance to the PIIN Leadership Team regarding its strategic directions and facilitates communications to neuroscience researchers across campus. |
| Finance | Initial funding of $13.7M to establish PIIN. Annual operational budget of $570,000 from a variety of sources including annual support from subsidy from EVPRP and Krenicki Director Endowment Funds |
| Data Source | • Purdue University Sponsored Program Services • Purdue Research Foundation – Office of Technology and Commercialization • Regenstrief Center for Healthcare Engineering and Regenstrief Institute (e.g., electronic healthcare records) • Government partners (e.g., Lewis Burke firm hired by Purdue University to provide information about new government initiatives that result in funding opportunities) • Online news resources and search engines |
| Data Access | • Funded research awards by various agencies (e.g., NIH, NSF, DOD, Michael J. Fox Foundation) • Funded research projects by industry partners • Tracking of patents granted and patents pending • Tracking progress of internally funded projects |
| Tech Capabilities | • Brain neurocircuitry mapping via high-resolution imaging and electrophysiology • Cutting-edge technologies for rodent behavioral analysis in the Purdue Animal Behavior Core • Human stem cell-based disease modeling in the Neuroscience Cell Engineering Core • Data science capabilities for analysis of large clinical and preclinical datasets • Project management for biomedical research • Research translation and commercialization |
| Projects | • Interdisciplinary projects at the interface of life sciences and engineering in addiction, hearing science, neurodegenerative disorders, neurodevelopmental disorders, and neurotrauma (funded by the PIIN Grand Challenges initiative) • Projects focused on key topics relevant to Alzheimer’s disease and related dementias (ADRDs), including disease etiology, animal models, biomarkers, and druggable targets (funded by the PIDD/PIIN ADRD Joint Program) • Projects addressing the role of the gut-brain axis in neurologic disorders (e.g. cognitive decline following recovery from COVID-19) • Projects addressing the impact of environmental exposures on susceptibility to neurodegenerative disease in animal models and humans • Data science projects aimed at classifying trajectories of disease progression for subtypes of CNS disorders, enabling improved predictions of health decline and strategies for personalized medicine • Wide array of extramurally funded projects relevant to nervous system function and dysfunction |
| Future Focus | • Map/modulate neurocircuitry spanning the gut-brain axis using innovative engineering technologies • Advance personalized medicine for neurological disorders by leveraging digital biomarkers • Interdisciplinary programs supported by large center grants • New opportunities for technology development and commercialization |
| Talent Development | • Graduate and undergraduate student research opportunities • Graduate & MD-PhD training • Graduate courses in neuroscience • Training of NIH T32 trainees through the Interdisciplinary Training Program in Auditory Neuroscience (TPAN) • Graduate student travel grants • Faculty and trainee mentoring (e.g., for extramural applications) • Post-Doctoral Fellowship in Neuroscience • Collaborative initiatives and workshops |
| Data Sharing Agreements | Project-dependent |
| Programs/ Publications | • News: https://www.purdue.edu/discoverypark/institute-for-integrative-neuroscience/news/index.php • Newsletters: https://www.purdue.edu/discoverypark/institute-for-integrative-neuroscience/resources/newsletters.php |